Five years after losing his wife and children in the terrorist attacks of 9/11, Charlie Fineman (Sandler), a once successful dentist who has now retreated from his life, unexpectedly bumps into his old college roommate Alan Johnson (Cheadle) on a Manhattan street corner. Alan, who is dealing with issues in his own family life, is shocked to see the change in his former gregarious friend. Their re-kindled relationship becomes a life-line for the two men, who are both in need of a trusted friend and their chance encounter soon becomes a life long friendship where both men emerge enriched and enlightened.

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