Martin Scorsese exhilaratingly adapts Joe Connelly's novel about Frank (Nicolas Cage), a paramedic working among the filth and mental desolation of New York City's Hell's Kitchen in the early 1990s. Lately he has been haunted by the visions of a beautiful 18 year-old girl whom he was unable to resuscitate. Soon after, another image begins to torment him, that of Mary (Patricia Arquette), a recovering drug addict who enters Frank's life when he attempts to save her father. His spiral into even further confusion is paralleled with his three driving partners: Larry (a boisterous John Goodman), whose advice to Frank is not to think about all the death and violence; Marcus (a scene-stealing Ving Rhames), a religious fanatic who uses his medical skills as propaganda for the Lord; and Walls (a maniacal Tom Sizemore), a loose cannon who has no sensible grounding whatsoever. In order to escape the madness that is consuming him, Frank asks, unsuccessfully, to be fired. He must ride out the nightmare, trying to redeem the lives of Rose, Mary, and himself in the process. Scorsese uses his camera to capture Frank's wavering mental state with tilted angles and fast-speed photography. In portraying the tormented Frank, Cage dives wholeheartedly into character, delivering another fiery performance.

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